The MDR1 defect stands for multidrug resistance transporter. This is a genetic disease of certain dog breeds, which makes them very sensitive to various drugs and medicines. The MDR1 gene is important for dogs because it prevents dangerous substances from entering the brain or nervous system and supports excretion in the liver and kidneys. It also reduces absorption in the intestines. Collies and Border Collies are particularly affected by the MDR1 defect. The genetic defect has also been detected in Shetland Sheepdogs, Australian Shepherds, German Shepherds and Labradors, among others.
The dog passes the MDR1 defect on during reproduction. A sick dog carries the defect from both its mother and father. If only one of the parents is affected by the MDR1 defect, only one affected gene is passed on. The young animal carries the defect but does not become ill. Instead, it passes on 50 percent of the defective genetic trait to its offspring.
To put it simply: Two sick animals have one sick puppy. Two healthy animals have one healthy puppy. If only one of the animals is sick, the puppy will carry the MDR1 defect but will remain healthy.
If you want to check for an MDR1 defect in your dog, there are DNA genetic tests that only require 0.5 milliliters of blood. For possible treatment, visit a veterinarian. They will explain to you the various medications that can be administered.
Sources:
AniCura
Laboratory for Clinical Diagnostics
Tierklinik Dr. Trillig
